NIIKURA实验室

研究方向：

1.  建立细胞分裂相关细胞信号通路的理论与实验模型

2.  肿瘤细胞和脑细胞中有丝分裂，细胞周期，染色体不稳定性以及表观遗传学的分子机制

3.  使用小鼠和斑马鱼模型研究人类癌症和发育疾病

选定的出版物, 所有出版物均经过同行评审; #第一作者, *共同通讯作者

1. Niikura Y#*, Kitagawa K#. E3 ligases for CENP-A. In: Catala A, editor. London, UK: IntechOpen [two book chapters]; 2022, In Press.

 2. Niikura Y#*, Fang L#, Kitagawa R#, Li P, Xi Y, You J, Gao Y, Kitagawa K*. Mass Spectrometry Analysis to Identify Ubiquitylation of EYFP-tagged CENP-A (EYFP-CENP-A). J. Vis. Exp. 2020(160). Epub 2020/07/01. doi: 10.3791/61138. PubMed PMID: 32597847. (# Equal contribution)

 3. Niikura Y#*, Kitagawa R#, Fang L, Kitagawa K*. CENP-A Ubiquitylation Is Indispensable to Cell Viability. Dev Cell. 2019;50(6):683-9 e6. Epub 2019/09/25. doi: 10.1016/j.devcel.2019.07.015. PubMed PMID: 31550462; PMCID: PMC6761987. (# Equal contribution)

 4. Niikura Y*, Kitagawa K*. The function of SUGT1 (the human homolog of SGT1), a co-chaperon.  Heat Shock Protein 90 in Human Diseases and Disorders. Dordrecht, Netherlands: Springer Nature Publishers [a book chapter]; 2019.

 5. Niikura Y*, Kitagawa R, Kitagawa K*. CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere. Molecules. 2019;24(3). Epub 2019/01/27. doi: 10.3390/molecules24030402. PubMed PMID: 30678315.

 6. Niikura Y, Kitagawa R, Ogi H, Kitagawa K. SGT1-HSP90 complex is required for CENP-A deposition at centromeres. Cell Cycle. 2017:1-12. doi: 10.1080/15384101.2017.1325039. PubMed PMID: 28816574.

 7. Niikura Y, Kitagawa R, Kitagawa K. CENP-A Ubiquitylation Is Required for CENP-A Deposition at the Centromere. Dev Cell. 2017;40(1):7-8. doi: 10.1016/j.devcel.2016.12.020. PubMed PMID: 28073011.

 8. Niikura Y, Kitagawa R, Kitagawa K. CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions. Cell Rep. 2016;15(1):61-76. doi: 10.1016/j.celrep.2016.03.010. PubMed PMID: 27052173; PMCID: PMC4826857.

 9. Niikura Y, Kitagawa R, Ogi H, Abdulle R, Pagala V, Kitagawa K. CENP-A

K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere. Dev Cell. 2015;32(5):589-603. Epub 2015/03/03. doi: 10.1016/j.devcel.2015.01.024. PubMed PMID: 25727006; PMCID: 4374629.