蒋青实验室

蒋青教授主要从事运动系统疾病基础和临床研究，共发表中文核心论文80余篇、SCI论文50余篇，包括Nature Medicine, Nature Genetic, ACS NANO，2007有篇论文被评为中国最有影响的百篇国际论文，文章总引用数为825次，单篇最高他引为119次。

共获得国家支撑项目一项、国家自然科学基金重大国际合作基金一项、国家杰出青年基金、卫生部行业基金子课题组长一项、国家自然科学基金面上项目2项，江苏省自然科学基金1项、南京市转化医学医学中心经费、南京市重大项目2项.

以第一完成人分别于2002获得江苏省科技进步三等奖、2009江苏省科技进步奖二等奖、2015教育部自然科学二等奖，并被推荐为2016年国家自然科学二等奖候选项目。是国内第一个在国际关节炎协会（OARSI）任职理事的学者，担任SICOT中国分会基础研究分会副主任委员、国际软骨损伤修复学会（ICRS）中国分会副主委。中华医学会运动医疗分会常委、下肢学组组长、中华医学会再生医学分会委员、软骨修复学组的副组长，中华医学会骨科分会关节炎工作组组长，本届江苏省运动医疗分会主任委员、骨科分会副主任委员、创伤分会副主任委员

担任多个SCI杂志编委，包括Osteoarthritis and Cartilage（IF=4.6）、BMC muscusketal disorder（section editor IF=1.577）, OsteopedicSurguey（IF=0.8），并担任多个一流杂志的审稿人员，同时作为主编创建了一本英文杂志（aoj.amegroups.com）。是《中华创伤杂志》、《中华骨与关节外科杂志》等国内多个中文核心期刊的编委。

研究方向：

1. 软骨修复

       研究通过小分子药物诱导自身滑膜源兴干细胞进行软骨损伤修复，可注射型钛纳米水凝胶在体内原位成胶并修复软骨损伤，其中研制的的软骨修复材料在兔软骨缺损模型中取得了良好的修复效果，相关结果已被ACS Nano 杂志收录。

2. 遗传学研究

       蒋青教授带领的研究团队首先在国际上发表中国人群骨关节炎群体遗传研究成果基于该研究成果发表的论文Replication of the association of the aspartic acid repeat

polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese被中国科学技术信息研究所评为2007年“中国百篇最具影响国际学术论文”。同时也开展了针对先天性髋关节发育不良以及部分罕见骨骼系统疾病的遗传学研究。

3. 生物3D打印技术

       本领域是实验室最近两年开展的新研究方向，主要包括生物3D打印材料的研发，在体生物3D打印技术的应用，在体生物3D打印设备的研发。目前已经开展了软骨损伤的在体生物3D打印的初步研究，不规则骨缺损的逆向建模及打印修复，组织工程材料的表面改性等。

1.    Nakajima M, Shi D, Dai J, et al. (2011) Replication studies in various ethnic populations do not support the association of the HIF-2_ SNP rs17039192 with knee osteoarthritis. Nat Med. 17(1):26-7. (IF= 30.357 )

2.    Shi D, Xu X, Ye Y, et al. (2016) Photo-cross-linked scaffold with kartogenin- encapsulated nanoparticles for cartilage regeneration. Acs Nano, 2016, 10(2):1292. (IF= 13.334 )

3.    Li L, Yang L, Yu F, et al. (2018). 3d printing individualized heel cup for improving the self-reported pain of plantar fasciitis. Journal of Translational Medicine, 16(1), 167. (IF= 4.197)

4.    Yu F, Han X, Zhang K, et al. Journal of biomedical materials research A, Online. (IF= 3.231)

5.    Lu K, Shi T, Li L, Zhang K, Zhu X, Shen S, et al. (2018). Zhuangguguanjie formulation protects articular cartilage from degeneration in joint instability-induced murine knee osteoarthritis. Am J Transl Res, 10(2), 411-421. (IF= 3.061)

6.    Lu K, Shi T, Shen S, et al. (2018). Egr1 deficiency disrupts dynamic equilibrium of chondrocyte extracellular matrix through ppar_/runx2 signaling pathways. American Journal of Translational Research, 10(6), 1620. (IF= 3.061)

7.    Yan W, Hao Z, Tang S, et al. A genome-wide association study identi_ es new genes associated with developmental dysplasia of the hip. Clinical Genetics accepted (IF=3.512)

8.    Yao Y, Qiao L, Song K, et al. (2018). Preoperative evaluation of soleal vein diameter by ultrasound is bene_ cial for prophylaxis of deep vein thrombosis after total knee or hip arthroplasty. BioMed Research International. Online. (IF=2.583)

9.    Dongyang Chen, Zhihong Xu, Dongquan Shi, Xusheng Qiu, Jin Dai, Tao Yuan, Wenjie Weng, Qing Jiang. Clinical outcome of Zweymüller total hip arthroplasty for patients with high congenital hip dislocation. Hip Int 2011; 21 ( 01 ): 071 – 075. IF=0.756

10.  Zhu L, Shi D, Dai J, Qin J, Fan J, Wang Z, Qiu X, Xu Z, Chen D, Jiang Q.   Lack of evidence for association between DVWA gene polymorphisms and developmental dysplasia of the hip in Chinese Han population. Rheumatol Int. 2011 Jul;31(7):883-7. IF=1.516

11.  Fan J, Shi D, Dai J, Zhu L, Qin J, Shao Z, Qiu X, Xu Z, Chen D, Jiang Q。 Genetic polymorphism of PITX1 in susceptibility to knee osteoarthritis in a Chinese Han population: a case-control study. Rheumatol Int. 2011 May;31(5):629-33. IF=1.516

12.  Xu Z, Chen D, Shi D, Jiang Q. Case Report: Osteochondral Avulsion Fracture of the Posteromedial Bundle of the PCL in Knee Hyperflexion. Clin Orthop Relat Res. 2012 Dec;470(12):3616-23. IF=2.735

13.  Shi D, Dai J, Ikegawa S, Jiang Q. Genetic study on developmental dysplasia of the hip. Eur J Clin Invest. 2012 Oct;42(10):1121-5. IF=2.734

14.  Hou H, Ge Z, Ying P, Dai J, Shi D, Xu Z, Chen D, Jiang Q. Biomarkers of deep venous thrombosis. J Thromb Thrombolysis. 2012 Oct;34(3):335-46. IF=2.169

15.  Nakajima M, Shi D, Dai J, Tsezou A, Zheng M, Norman PE, Chou CH, Lee MT, Hwang JY, Kim DH, Takahashi A, Ikegawa S, Jiang Q.A large-scale replication study for the association of rs17039192 in HIF-2α with knee osteoarthritis.J Orthop Res. 2012 Aug;30(8):1244-8. IF=2.986

16.  Ye S, Dongyang C, Zhihong X, Dongquan S, Jin D, Jianghui Q, Jizhen Q, Pu Y, Huacheng H, Wei S, Qing J. The incidence of deep venous thrombosis after arthroscopically assisted anterior cruciate ligament reconstruction. Arthroscopy. 2013 Apr;29(4):742-7.  IF=3.103

17.  Qin J, Dai J, Xu Z, Chen D, Qin J, Shi D, Teng H, Jiang Q. Genetic Polymorphism of NOS3 with Susceptibility to Deep Vein Thrombosis after Orthopedic Surgery: A Case-Control Study in Chinese Han Population. PLoS One. 2013 Jul 26;8(7):e70033.  IF=3.73

18.  Jizheng Qin, Zhihong Xu, Dongquan Shi, Dongyang Chen, Jin Dai, Huajian Teng, Qing Jiang. Deep vein thrombosis after total hip arthroplasty and total knee arthroplasty in patients with previous ischemic stroke.The International Journal of Lower Extremity Wound. 2013 Dec;12(4):316-9. IF=1.25

19.  Wang C, Yang F, Xu Z, Shi D, Chen D, Dai J, Gu N, Jiang Q*. Intravenous release of NO from lipidic microbubbles accelerates deep vein thrombosis resolution in a rat model. Thromb Res. 2013 Jan;131(1):e31-8. IF= 3.1

20.  Zhihong Xu , Dongquan Shi , Chengji Zhang, Dongyang Chen , Jin Dai , Huajian Teng , Qing Jiang. Postoperative plasma D-dimer value for predicting deep venous thrombosis following hip arthroplasty with nadroparin prophylaxis。 Hip Int 2013; 23 (4) : 411 -416. IF=0.756

21.  Shi D, Xu X, Xu Z, Nakamura T, Pang Y, Yao C, Wang F, Chen D, Dai J, Jiang Q.  P-selectin: an unpredicted factor for deep vein thrombosis after total hip arthroplasty.  Biomed Res Int. 2014;2014:783967. doi: 10.1155/2014/783967. Epub 2014 Jun 25  IF=2.706

22.  Shi D, Xu X, Song K, Xu Z, Dai J, Chen D, Jiang Q.  Comparison of venous thromboembolism after total hip arthroplasty between ankylosing spondylitis and osteoarthritis.Biomed Res Int. 2014;2014:712895. doi: 10.1155/2014/712895. Epub 2014 Jun 4. IF=2.706

23.  Dai X, Wang C, Dai J, Shi D, Xu Z, Chen D, Teng H, Jiang Q. Association of single nucleotide polymorphisms in estrogen receptor alpha gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population.  Biomed Res Int. 2014;2014:151457. doi: 10.1155/2014/151457. Epub 2014 Mar 17  IF=2.706

24.  Ye Sun, Dongyang Chen, Zhihong Xu, Dongquan Shi, Jin Dai, Jianghui Qin, Qing Jiang.  Incidence of Symptomatic and Asymptomatic Venous Thromboembolism After Elective Knee Arthroscopic Surgery: A Retrospective Study With Routinely Applied Venography.  Arthroscopy, Vol. 30, Issue 7, p818–822.  IF=3.191

25.  Ye Sun, Dongyang Chen, Zhihong Xu, Dongquan Shi, Jin Dai, Jianghui Qin, Jizhen Qin, Qing Jiang.  Deep Venous Thrombosis After Knee Arthroscopy: A Systematic Review and Meta-Analysis.  Arthroscopy, Vol. 30, Issue 3, p406–412.  IF=3.191

26.  Shi D, Sun W, Xu X, Hao Z, Dai J, Xu Z, Chen D, Teng H, Jiang Q. A replication study for the association of rs726252 in PAPPA2 with developmental dysplasia of the hip in Chinese Han population.  Biomed Res Int. 2014;2014:979520. doi: 10.1155/2014/979520. Epub 2014 Feb 3. IF=2.706

27.  Yang X, Li M, Chen D, Shi D, Zhou Z, Zhu B, Jiang Q. Diffusion tensor imaging for anatomical and quantitative evaluation of the anterior cruciate ligament and ACL grafts: a preliminary study. J Comput Assist Tomogr. 2014,38(4):489-494. If=1.601

28.  Hao Z, Dai J, Shi D, Xu Z, Chen D, Zhao B, Teng H, Jiang Q. Association of a single nucleotide polymorphism in HOXB9 with developmental dysplasia of the hip: a case-control study.  J Orthop Res. 2014 Feb;32(2):179-82. IF=2.88

29.  Lu Jingwei, Sun Ye, Ge Qiting, Teng Huajian, Jiang Qing.  Histone deacetylase 4 alters cartilage homeostasis in human osteoarthritis.  BMCMusculoskeletalDisorders.2014,15:438.DOI:10.1186/1471-2474-15-438.  IF=1.90

30.  T. Jiang,1 A. Qin,2,3 Z.Y. Shao,4 B. Tian,3 Z.J. Zhai,3 H.W. Li,3 Z.A. Zhu,3 K.R. Dai,3H. Zheng Ming,2 Y.P. Yu,4** and Q. Jiang1。 OA10 Is a Novel p38alpha Mitogen‐Activated Protein Kinase Inhibitor That Suppresses Osteoclast Differentiation and Bone Resorption。 Journal of Cellular Biochemistry。 115:959–966 (2014)。 IF=3.263

31.  Yang X, Chen D, LI M, et al. Diffusion Tensor Imaging of the Anterior Cruciate Ligament Graft After Reconstruction: Repeatability and Diffusion Tensor Imaging Metrics. J Comput Assist Tomogr. 2015,39(2):244-249.  IF=1.601 

32.  Xingquan Xu, Dongquan Shi*, Yeshuai Shen, Zhihong Xu, Jin Dai, Dongyang Chen, Huajian Teng and Qing Jiang*. Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule Compound kartogenin. Arthritis Research&Therapy。2015 Feb 2;17:20。 IF=3.753 

33.  Xu Z,Dai X,Yao Y,Shi D,Chen D,Dai J,Teng H,Jiang Q.  Higher Levels of Serum Triglycerides Were Associated With Postoperative Deep Vein Thrombosis After Total Hip Arthroplasty in Patients With Nontraumatic Osteonecrosis of the Femoral Head. Int J Low Extrem Wounds. 2015 Jun 1. pii: 1534734615580017. IF=1.194

34.  Sun Y,Wang C,Hao Z,Dai J,Chen D,Xu Z,Shi D,Mao P,Teng H,Gao X,Hu Z, Shen H,Jiang Q. A common variant of ubiquinol-cytochrome c reductase complex is associated with DDH. PLoS One. 2015 Apr 7;10(4):e0120212. doi: 10.1371/journal.pone.0120212. eCollection 2015. IF=3.234 

35.  Xu Z,Li L,Shi D,Chen D,Dai J,Yao Y,Teng H,Jiang Q. The level of red cell distribution width cannot identify deep vein thrombosis in patients undergoing total joint arthroplasty. Blood Coagul Fibrinolysis. 2015Apr;26(3):298-301.doi:10.1097/MBC.0000000000000239. IF=1.38 

36.  Shi D,Xu X,Guo A,Dai J,Xu Z,Chen D,Jiang Q. Bone cement solidifiliation influence the limb alignment and gap balance during TKA. Biomed Res Int. 2015;2015:109402. doi: 10.1155/2015/109402. IF=2.706

37.  Zhen Rong, Zhihong Xu, Qing Jiang et al.  Deep venous thrombosis in the nonoperated leg after primary major lower extremity arthroplasty: a retrospective study based on diagnosis using venography.  Blood Coagulation and Fibrinolysis 2015, 26:762–766.  IF=1.403

38.  Dawei Cai, Shasha Yin , Jun Yang, Qing Jiang* and Wangsen Cao。 Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis. Arthritis Research & Therapy (2015) 17:269 DOI 10.1186/s13075-015-0774-3。 IF=3.75

39.  Dawei Cai , Wan Feng , Qing Jiang。Acid-suppressive medications and risk of fracture: an updated meta-analysis. Int J Clin Exp Med 2015;8(6):8893-8904。 IF=1.277

40.  Zhihong Xu, Ping Mao, Dongyang Chen, Dongquan Shi, Jin Dai, Yao Yao, Qing Jiang.  Tenosynovial giant cell tumor arising from the posterior cruciate ligament: a case report and literature reviewInt J Clin Exp Pathol. 2015;8(6):6835-6840. IF=1.891 

41.  Junfei Wang,Jin Xiong,Zhihong Xu,Hongfei Shi,Jin Dai,Qing Jiang。 Short-Term Effects of Discoid Lateral Meniscectomy on the Axial Alignment of the Lower Limb in Adolescents。 J Bone Joint Surg Am。2015 Feb 04;97(3):201-207。 IF=5.28

42.  Shi D, Xu X, Ye Y, Song K, Cheng Y, Di J, Hu Q, Li J, Ju H, Jiang Q, Gu Z. Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration. ACS Nano. 2016 Jan 26;10(1):1292-9. IF=12.881

序号	项目名称	项目来源	项目起迄时间	项目经费（万元）	第一负责人
1	代谢性疾病及神经疾病相关基因的大鼠基因剔除模型建立	国家科技支撑计划 2015BAI08B02	2014.01-2017.12	1000	蒋青
2	发育性髋关节发育不良家系的全外显子组测序	国家自然科学基金国际合作项目 81420108021	2015.01-2019.12	300	蒋青
3	microRNA 作为早期诊断深静脉血栓生物标志物的研究	国家自然科学基金面上项目 81271945	2013.01-2016.12	70	蒋青
4	临床新技术安全性与效果评价——关节置换术安全性与效果评价	卫生部公益性行业科研专项 201302007	2013.06-2016.06	70	蒋青

硕士生：
乔梁 qiaoliang@nicemice.cn
博士生：
李逸轩 liyx@nicemice.cn	敏思聪 minsc@nicemice.cn	周盛 zhousheng@nicemice.cn
技术员：
葛启婷 geqt@nicemice.cn