陈迪实验室

研究方向：
      衰老表现为由于时间的推移所带来的功能性下降和死亡率上升。对于衰老及其相关疾病（心血管疾病、糖尿病、癌症、神经退化性疾病等）的分子机理的认识是基础生物学和生物医学研究中的重要课题。近年来的研究在分子水平表明衰老能够被高度保守的信号传导通路所调节，遗传和环境因素的改变可以显著的延长寿命并且推迟甚至消除与衰老相关的疾病的发生。秀丽线虫（C. elegans）由于其生活史的简单性和遗传学研究的易操作性，已经被广泛的应用于现代生物学研究。我们实验室以秀丽线虫为模式生物，通过遗传学、分子细胞生物学和系统生物学手段，探索衰老及其相关疾病的分子机理。
主要研究方向有:

（1）Insulin/IGF-1和mTOR信号通路组织特异性调节衰老的基因组学研究；

（2）饮食限制（dietary restriction）延缓衰老的分子机理；

（3）RNA代谢影响衰老及其相关疾病的机制研究。

*，通讯作者

1.     Di Wu^#, Waijiao Cai^#, Xuan Zhang, Jianfeng Lan, Lina Zou, Samuel J. Chen, Zixing Wu, Di Chen*, Inhibition of PAR-1 Delays Aging via Activating AMPK in C. elegans. Aging, 2020, DOI: 10.18632/aging.104180 (^#, co-first authors)

2.     Jianfeng Lan^#, Jarod A. Rollins^#, Xiao Zang^#, Di Wu^#, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi*, Aric N. Rogers*, Di Chen*, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Reports, 2019, 28(4): 1050-1062.e6. (^#, co-first authors)

3.     Lina Zou, Di Wu, Xiao Zang, Zi Wang, Zixing Wu, Di Chen*, Construction of a germline-specific RNAi tool in C. elegans. Scientific Reports, 2019, 9(1): 2354.

4.     Zhen Zhu, Weijie Chen, Beitong Tian, Yulong Luo, Jianfeng Lan, Di Wu, Di Chen, Zixin Wang, Dejing Pan, Using Microfluidic Impedance Cytometry to Measure C. elegans Worms and Identify Their Developmental Stages. Sensors and Actuators B: Chemical, 2018, 275: 470-482.

5.     Dan Wang, Lei Hou, Shuhei Nakamura, Ming Su, Fang Li, Weiyang Chen, Yizhen Yan, Christopher D. Green, Di Chen, Hong Zhang, Adam Antebi, Jing-Dong J. Han, LIN-28 Balances Longevity and Germline Stem Cell Number in Caenorhabditis elegans through let-7/AKT/DAF-16 Axis. Aging Cell, 2017, 16(1): 113-124.

6.     Lei Gao, Rujun Zhang, Jianfeng Lan, Ruonan Ning, Di Wu, Di Chen*, Weimin Zhao*, b-Dihydroagarofuran-type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-extending Effects on the Nematode Caenorhabditis elegans. Journal of Natural Products, 2016, 79(12): 3039-3046.

7.     Lei Hou^#, Dan Wang^#, Di Chen^#, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, William B. Mair, Jing-Dong J. Han, A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metabolism, 2016, 23(3): 529-540. (^#, co-first authors)

8.     Jianfeng Lan, Xuan Zhang, Di Chen*, Molecular Mechanisms of Dietary Restriction in Aging - Insights from Caenorhabditis elegans Research, Science China Life Sciences, 2015, 58(4): 352-358.

9.     Di Chen^#, *, Jiuli Zhang^#, Justin Minnerly, Tiffany Kaul, Donald L. Riddle, Kailiang Jia*, daf-31 Encodes the Catalytic Subunit of N alpha-Acetyl Transferase that Regulates Caenorhabditis elegans Development, Metabolism and Adult Lifespan, PLoS Genetics, 2014, 10(10): e1004699. (^#, co-first authors)

10.   陈迪^*，秀丽线虫胰岛素类生长因子和雷帕霉素受体信号通路对衰老的调节作用，生物化学与生物物理进展, 2014, 41(3): 305-312.

11.   Di Chen*, Patrick Wai-Lun Li, Benjamin A. Goldstein, Waijiao Cai, Emma Lynn Thomas, Fen Chen, Alan E. Hubbard, Simon Melov, Pankaj Kapahi*, Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans, Cell Reports, 2013, 5(6): 1600-1610.

12.   Aric N. Rogers, Di Chen, Gawain McColl, Greg Czerwieniec, Krysta Felkey, Bradford W. Gibson, Alan Hubbard, Simon Melov, Gordon J. Lithgow, Pankaj Kapahi, Life Span Extension via eIF4G Inhibition is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans, Cell Metabolism, 2011, 14(1): 55-66.

13.   Pankaj Kapahi, Di Chen, Aric N. Rogers, Subhash D. Katewa, Patrick Wai-Lun Li, Emma L. Thomas, Lutz Kockel, With TOR, Less Is More: a Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging, Cell Metabolism, 2010, 11(6): 453-465.

14.   Di Chen, Emma Lynn Thomas, Pankaj Kapahi, HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans, PLoS Genetics, 2009, 5(5): e1000486.

15.   Russell Bell, Alan Hubbard, Rakesh Chettier, Di Chen, John P. Miller, Pankaj Kapahi, Mark Tarnopolsky, Sudhir Sahasrabuhde, Simon Melov, Robert E. Hughes, A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species, PLoS Genetics, 2009, 5(3): e1000414.

16.   Di Chen, Donald L. Riddle, Function of the PHA-4/FOXA Transcription Factor during C. elegans Post-Embryonic Development, BMC Developmental Biology, 2008, 8(1): 26.

17.   Di Chen, Kally Z. Pan, Julia E. Palter, Pankaj Kapahi, Longevity Determined by Developmental Arrest Genes in Caenorhabditis elegans, Aging Cell, 2007, 6(4): 525-533.

18.   Kally Z. Pan, Julia E. Palter, Aric N. Rogers, Anders Olsen, Di Chen, Gordon J. Lithgow, Pankaj Kapahi, Inhibition of mRNA Translation Extends Lifespan in Caenorhabditis elegans, Aging Cell, 2007, 6(1): 111-119.

19.   Kailiang Jia, Di Chen, Donald L. Riddle, The TOR Pathway Interacts with the Insulin Signaling Pathway to Regulate C. elegans Larval Development, Metabolism and Life Span, Development, 2004, 131(16): 3897-3906.

20.   Di Chen, Yanjie Liu, Jiabi Zhu, Shanjiong Shen, Guanqiao Yu, Analysis of the Downstream Region of nodD3 P1 Promoter by Deletion and Complementation Tests in Sinorhizobium meliloti, Science China C Life Sciences, 2003, 46(2): 165-173.