甘振继实验室

研究方向：
       线粒体重塑与代谢疾病。主要是运用基因工程小鼠为模式动物，通过分子细胞生物学手段探索包括肥胖症、糖尿病与慢性肌肉病在内的代谢疾病发生的分子机制。主要的研究方向有：1）骨骼肌线粒体代谢重塑与疾病的发生；2）利用全基因组染色体状态谱动态分析及代谢组学分析的方法，研究运动代谢的分子基础；3）重要细胞器的交互对话在代谢稳态调节中的作用机制。目前承担了包括国家973计划、国自然面上项目在内的多项研究课题。

1. Guo Q#, Xu Z#, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, ZhuY, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B,Gan Z*. Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesityindependently of ATF4.Science Advances.2022; 8(30): eabo0340.
2. Yin Y, Xu D, Mao Y,Gan Z*. Comments on 'FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics'.J Mol Cell Biol.2022; mjac033.
3. Yin Y#, Xu D#, Mao Y#, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X,Gan Z*. FNIP1 regulates white adipose tissue browning and systemic glucose homeostasis by shaping intracellular calcium dynamics.J Exp Med.2022;219(5): e20212491.
4. Xu Z#, Fu T#, Guo Q#, Zhou D, Sun W, Zhou Z, Chen X, Zhang Z, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu M, Fei W, Lu B,Gan Z*. Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.Nat Commun.2022; 13(1):894.
5. He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J,Gan Z*and Liu Y*. IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay.J Clin Invest.2021;131(17): e143737.
6. Xiao L#, Liu J#, Sun Z#, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T,Zhou W, Zhu Y, Chen XW, Li J, Chen S, Xie X,Gan Z*.AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1.PLoS Genet.2021; 17(3): e1009488.
7. Xiang C, Zhang Y, Chen Q, Sun A, Peng Y, Zhang G, Zhou D, Xie Y, Hou X, Zheng F, Wang F,Gan Z, Chen S, Liu G.Increased glycolysis in skeletal muscle coordinates with adipose tissue in systemic metabolic homeostasis.J Cell Mol Med.2021; 25(16):7840-7854.
8. Liu L#, Ding C#, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K,Gan Z*.Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction.J Clin Invest. 2020, 130(9):4710-4725.
9. Wu D, Zang YY, Shi YY, Ye C, Cai WM, Tang XH, Zhao L, Liu Y,Gan Z, Chen GQ, Xu Y, Yang JJ, Shi YS*.Distant coupling between RNA editing and alternative splicing of the osmosensitive cation channel Tmem63b.J Biol Chem.2020,295(52):18199-18212.
10. Chen X, Gao YQ, Zheng YY, Wang W, Wang P, Liang J, Zhao W, Tao T, Sun J, Wei L, Li Y, Zhou Y,Gan Z, Zhang X, Chen HQ*, Zhu MS*.The intragenic microRNAmiR199A1in the dynamin 2 gene contributes to the pathology of X-linked centronuclear myopathy.J Biol Chem.2020;295(26):8656-8667.
11. Liu L#, Cai J#, Wang H#, Liang X#, Zhou Q#, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, XueB, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW*,Gan Z*.Coupling of COPII vesicle trafficking to nutrient availability by the IRE1a-XBP1s axis.Proc Natl Acad Sci USA. 2019; 116(24): 11776-11785.
12. Xu Z, Fu T, Guo Q, Sun W,Gan Z*. Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity.Pharmacol Res.2018; 141:176-180.
13. Zhu Z, Wang Z, Zhang C, Wang Y, Zhang H,Gan Z, Guo Z, Wang X.Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism.Chem Sci.2019;10(10):3089-3095.
14. Gan Z*, Fu T, Kelly DP*, Vega RB*. Skeletal muscle mitochondrial remodeling in exercise and diseases.Cell Research.2018; 28(10): 969-980.
15. Fu T, Xu Z, Lin L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, Zhu M, Chen Q*,Gan Z*. Mitophagydirectsmuscle-adiposecrosstalktoalleviate dietary obesity.Cell Reports. 2018; 23: 1357–1372.
16. Ma Y, Sun L, Li J, Hu Y,Gan Z, Zong G, Zheng H, Jin Q, Li H, Hu FB, Zeng R, Sun Q, Lin X. Erythrocyte PUFAs, circulating acylcarnitines, and metabolic syndrome risk: a prospective study in Chinese.J Lipid Res.2019; 60(2):421-429.
17. Yang J, Cao Q, Zhang H, Hao L, Zhou D,Gan Z, Li Z, Tong YX, Ji LN, Mao ZW. Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium (I)-DCA conjugate.Biomaterials.2018; 176:94-105.
18. Yang J, Zhao JX, Cao Q, Hao L, Zhou D,Gan Z, Ji LN, Mao ZW.Simultaneously Inducing and Tracking Cancer Cell Metabolism Repression by Mitochondria-Immobilized Rhenium (I) Complex.ACS Appl Mater Interfaces.2017;9(16):13900-13912.
19. Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega R, Zhu MS, Kelly DP, Gao X,Gan Z*. Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit.EMBO Mol Med.2016; 8(10):1212-1228. Cover story.
20. Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Lai L, Kong Y, Xie H, Yi F, Lai L, Vega R, Kelly DP, Smith SR,Gan Z*. Exercise inducible lactate dehydrogenase B regulates mitochondrial function in skeletal muscle.J. Biol. Chem.2016; 291(49):25306-25318.
21. Kong Y*, Li K, Fu T, Wan C, Zhang D, Song H, Zhang Y, Liu N,Gan Z*, Yuan L*. Quercetin ameliorates Aβ toxicity in Drosophila AD model by modulating cell cycle-related protein expression.Oncotarget. 2016;7(42):67716-67731.
22. Liu J, Liang X,Gan Z*. Transcriptional regulatory circuits controlling muscle fiber type switching.Sci China Life Sci.2015;58(4):321-7.
23. Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du J, Li CJ,Gan Z, Gao X, Chen HQ, Zhu MS. Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance.Proc Natl Acad Sci USA.2015;112(44):13627-32.
24. Kong Y, Liang X, Liu L, Zhang D, Wan C,Gan Z, Yuan L. High throughputsequencing identifies microRNAs mediating α-synuclein toxicity by targetingneuroactive-ligand receptor interaction pathway in early stage of drosophilaparkinson's disease model.PLoS One.2015; 10(9):e0137432.
25. Gan Z, Rumsey J, Hazen BC, Lai L, Leone TC, Vega RB, Xie H, Conley KE, Auwerx J, Smith SR, Olson EN, Kralli A, Kelly DP. Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism.J Clin Invest.2013;123(6):2564-75.
26. Zhang Y,Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L, Liu Y. A role for protein inhibitor of activated STAT 1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.J Biol Chem.2012;287(45):37973-85.
27. Gan Z, Burkart-Hartman EM, Han DH, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP. The nuclear receptor PPARb/d programs muscle glucose metabolism in cooperation with AMPK and MEF2.Genes Dev.2011;25(24):2619-30.
28. Yang L, Huang P, Li F, Zhao L, Zhang Y, Li S,Gan Z, Lin A, Li W, Liu Y. c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.PLoS One.2012;7(11): e48611.
29. George CX,Gan Z, Liu Y, Samuel CE. Adenosine deaminases acting on RNA, RNA editing, and interferon action (invited review).J Interferon Cytokine Res.2011;31(1):99-117.
30. Yang L, Zhao L,Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W, Liu Y. Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.FASEB J.2010;24(10):3720-32.
31. Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W, Liu Y. RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells.J Biol Chem.2006; 281(44):33386-94.