高翔实验室

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高翔博士，1994年获美国Thomas Jefferson University发育生物学与解剖学专业博士学位，南京大学模式动物研究所创始人。2000年受聘为南京大学教授，2002年受聘为博士生导师及教育部长江奖励计划特聘教授，2008年获国家杰出青年科学基金。国家科技进步二等奖和教育部科技进步特等奖获得者。

1. Zou, D., J. Pei, J. Lan, H. Sang, H. Chen, H. Yuan, D. Wu, Y. Zhang, Y. Wang, D. Wang, Y. Zou, D. Chen, J. Ren, X. Gao, and Z. Lin, A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption. EBioMedicine, 2020. 52: p. 102652.

2. Zheng, J., D. Wang, Q. Chen, Q. Liu, Z. Lin, Q. Hu, X. Wu, X. Gao, Q. Li, and J. Ren, Hypertonic saccharide solution delays pyroptosis in murine macrophages regardless of the membrane binding of gasdermin D N-terminal. Eur J Immunol, 2020. 50(3): p. 464-467.

3. Zhang, T., P. Xie, Y. Dong, Z. Liu, F. Zhou, D. Pan, Z. Huang, Q. Zhai, Y. Gu, Q. Wu, N. Tanaka, Y. Obata, A. Bradley, C.J. Lelliott, L.M.J. Nutter, C. McKerlie, A.M. Flenniken, M.F. Champy, T. Sorg, Y. Herault, M.H. Angelis, V.G. Durner, A.M. Mallon, S.D.M. Brown, T. Meehan, H.E. Parkinson, D. Smedley, K.C.K. Lloyd, J. Yan, X. Gao, J.K. Seong, C.L. Wang, R. Sedlacek, Y. Liu, J. Rozman, L. Yang, and Y. Xu, High-throughput discovery of genetic determinants of circadian misalignment. PLoS Genet, 2020. 16(1): p. e1008577.

4. Wang, D., J. Zheng, Q. Hu, C. Zhao, Q. Chen, P. Shi, Q. Chen, Y. Zou, D. Zou, Q. Liu, J. Pei, X. Wu, X. Gao, J. Ren, and Z. Lin, Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis. Cell Death Differ, 2020. 27(2): p. 466-481.

5. Lloyd, K.C.K., D.J. Adams, G. Baynam, A.L. Beaudet, F. Bosch, K.M. Boycott, R.E. Braun, M. Caulfield, R. Cohn, M.E. Dickinson, M.S. Dobbie, A.M. Flenniken, P. Flicek, S. Galande, X. Gao, A. Grobler, J.D. Heaney, Y. Herault, M.H. de Angelis, J.R. Lupski, S. Lyonnet, A.M. Mallon, F. Mammano, C.A. MacRae, R. McInnes, C. McKerlie, T.F. Meehan, S.A. Murray, L.M.J. Nutter, Y. Obata, H. Parkinson, M.S. Pepper, R. Sedlacek, J.K. Seong, T. Shiroishi, D. Smedley, G. Tocchini-Valentini, D. Valle, C.L. Wang, S. Wells, J. White, W. Wurst, Y. Xu, and S.D.M. Brown, The Deep Genome Project. Genome Biol, 2020. 21(1): p. 18.

6. Jiang, H., L. Zhang, X. Liu, W. Sun, K. Kato, C. Chen, X. Li, T. Li, Z. Sun, W. Han, F. Zhang, Q. Xiao, Z. Yang, J. Hu, Z. Qin, R.H. Adams, X. Gao, and Y. He, Angiocrine FSTL1 (Follistatin-Like Protein 1) Insufficiency Leads to Atrial and Venous Wall Fibrosis via SMAD3 Activation. Arterioscler Thromb Vasc Biol, 2020. 40(4): p. 958-972.

7. Huang, C., T. Liu, Q. Wang, W. Hou, C. Zhou, Z. Song, Y.S. Shi, X. Gao, G. Chen, Z. Yin, and Y. Hu, Loss of PP2A Disrupts the Retention of Radial Glial Progenitors in the Telencephalic Niche to Impair the Generation for Late-Born Neurons During Cortical Developmentdagger. Cereb Cortex, 2020.

8. Zhou, S., Y. Li, L. Qiao, Y. Ge, X. Huang, X. Gao, H. Ju, W. Wang, J. Zhang, J. Yan, H. Teng, and Q. Jiang, Inactivation of Lkb1 in postnatal chondrocytes leads to epiphyseal growth-plate abnormalities and promotes enchondroma-like formation. FASEB J, 2019. 33(8): p. 9476-9488.

9. Zheng, M., D. Li, Z. Zhao, D. Shytikov, Q. Xu, X. Jin, J. Liang, J. Lou, S. Wu, L. Wang, H. Hu, Y. Zhou, X. Gao, and L. Lu, Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection. Proc Natl Acad Sci U S A, 2019. 116(25): p. 12422-12427.

10. Yuan, X., X. Qin, D. Wang, Z. Zhang, X. Tang, X. Gao, W. Chen, and L. Sun, Mesenchymal stem cell therapy induces FLT3L and CD1c(+) dendritic cells in systemic lupus erythematosus patients. Nat Commun, 2019. 10(1): p. 2498.

11. Xu, Q., X. Jin, M. Zheng, D. Rohila, G. Fu, Z. Wen, J. Lou, S. Wu, R. Sloan, L. Wang, H. Hu, X. Gao, and L. Lu, Phosphatase PP2A is essential for TH17 differentiation. Proc Natl Acad Sci U S A, 2019. 116(3): p. 982-987.

12. Wang, Y., P. Shi, Q. Chen, Z. Huang, D. Zou, J. Zhang, X. Gao, and Z. Lin, Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. J Mol Cell Biol, 2019.

13. Wang, J., R. Xie, X. Kou, Y. Liu, C. Qi, R. Liu, W. You, J. Gao, and X. Gao, A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction. Mol Brain, 2019. 12(1): p. 51.

14. Quan, C., M. Li, Q. Du, Q. Chen, H. Wang, D. Campbell, L. Fang, B. Xue, C. MacKintosh, X. Gao, K. Ouyang, H.Y. Wang, and S. Chen, SPEG Controls Calcium Reuptake Into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain. Circ Res, 2019. 124(5): p. 712-726.

15. Ma, P., N.N. Song, Y. Li, Q. Zhang, L. Zhang, L. Zhang, Q. Kong, L. Ma, X. Yang, B. Ren, C. Li, X. Zhao, Y. Li, Y. Xu, X. Gao, Y.Q. Ding, and B. Mao, Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. Cell Rep, 2019. 28(2): p. 541-553 e4.

16. Lai, S.S., X. Fu, Q. Cheng, Z.H. Yu, E.Z. Jiang, D.D. Zhao, D.C. Yu, Y.D. Qiu, X. Gao, H.X. Ju, W. Wang, Q. Jiang, M.S. Zhu, C.J. Li, and B. Xue, HSC-specific knockdown of GGPPS alleviated CCl4-induced chronic liver fibrosis through mediating RhoA/Rock pathway. Am J Transl Res, 2019. 11(4): p. 2382-2392.

17. Giannuzzi, G., P.J. Schmidt, E. Porcu, G. Willemin, K.M. Munson, X. Nuttle, R. Earl, J. Chrast, K. Hoekzema, D. Risso, K. Mannik, P. De Nittis, E.D. Baratz, Y. Herault, X. Gao, C.C. Philpott, R.A. Bernier, Z. Kutalik, M.D. Fleming, E.E. Eichler, and A. Reymond, The Human-Specific BOLA2 Duplication Modifies Iron Homeostasis and Anemia Predisposition in Chromosome 16p11.2 Autism Individuals. Am J Hum Genet, 2019. 105(5): p. 947-958.

18. Geng, L., X. Tang, K. Zhou, D. Wang, S. Wang, G. Yao, W. Chen, X. Gao, W. Chen, S. Shi, N. Shen, X. Feng, and L. Sun, MicroRNA-663 induces immune dysregulation by inhibiting TGF-beta1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Cell Mol Immunol, 2019. 16(3): p. 260-274.

19. Gao, J., A. Qin, D. Liu, R. Ruan, Q. Wang, J. Yuan, T.S. Cheng, A. Filipovska, J.M. Papadimitriou, K. Dai, Q. Jiang, X. Gao, J.Q. Feng, H. Takayanagi, C. Zhang, and M.H. Zheng, Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network. Sci Adv, 2019. 5(11): p. eaaw7215.

20. Dai, J., S. Zhou, Q. Ge, J. Qin, J. Li, H. Ju, Y. Cao, M. Zheng, C. Li, X. Gao, H. Teng, and Q. Jiang, Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression. J Orthop Surg Res, 2019. 14(1): p. 59.

21. Chen, Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z. Huang, J. Ren, Z. Lin, and X. Gao, GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol, 2019. 11(6): p. 496-508.

22. Chen, Q., P. Shi, D. Wang, Q. Liu, X. Li, Y. Wang, D. Zou, Z. Huang, X. Gao, and Z. Lin, Epidermis-Activated Gasdermin-A3 Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3 Signaling. Am J Pathol, 2019. 189(5): p. 1041-1052.

23. Zou, J., B. Lai, M. Zheng, Q. Chen, S. Jiang, A. Song, Z. Huang, P. Shi, X. Tu, D. Wang, L. Lu, Z. Lin, and X. Gao, CD4+ T cells memorize obesity and promote weight regain. Cell Mol Immunol, 2018. 15(6): p. 630-639.

24. Yu, F., X. Han, K. Zhang, B. Dai, S. Shen, X. Gao, H. Teng, X. Wang, L. Li, H. Ju, W. Wang, J. Zhang, and Q. Jiang, Evaluation of a polyvinyl alcohol-alginate based hydrogel for precise 3D bioprinting. J Biomed Mater Res A, 2018.

25. Wang, Q., J. Tang, S. Jiang, Z. Huang, A. Song, S. Hou, X. Gao, and H.B. Ruan, Inhibition of PPARgamma, adipogenesis and insulin sensitivity by MAGED1. J Endocrinol, 2018.

26. Rozman, J., B. Rathkolb, M.A. Oestereicher, C. Schutt, A.C. Ravindranath, S. Leuchtenberger, S. Sharma, M. Kistler, M. Willershauser, R. Brommage, T.F. Meehan, J. Mason, H. Haselimashhadi, I. Consortium, T. Hough, A.M. Mallon, S. Wells, L. Santos, C.J. Lelliott, J.K. White, T. Sorg, M.F. Champy, L.R. Bower, C.L. Reynolds, A.M. Flenniken, S.A. Murray, L.M.J. Nutter, K.L. Svenson, D. West, G.P. Tocchini-Valentini, A.L. Beaudet, F. Bosch, R.B. Braun, M.S. Dobbie, X. Gao, Y. Herault, A. Moshiri, B.A. Moore, K.C. Kent Lloyd, C. McKerlie, H. Masuya, N. Tanaka, P. Flicek, H.E. Parkinson, R. Sedlacek, J.K. Seong, C.L. Wang, M. Moore, S.D. Brown, M.H. Tschop, W. Wurst, M. Klingenspor, E. Wolf, J. Beckers, F. Machicao, A. Peter, H. Staiger, H.U. Haring, H. Grallert, M. Campillos, H. Maier, H. Fuchs, V. Gailus-Durner, T. Werner, and M. Hrabe de Angelis, Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun, 2018. 9(1): p. 288.

27. Moore, B.A., B.C. Leonard, L. Sebbag, S.G. Edwards, A. Cooper, D.M. Imai, E. Straiton, L. Santos, C. Reilly, S.M. Griffey, L. Bower, D. Clary, J. Mason, M.J. Roux, H. Meziane, Y. Herault, C. McKerlie, A.M. Flenniken, L.M.J. Nutter, Z. Berberovic, C. Owen, S. Newbigging, H. Adissu, M. Eskandarian, C.W. Hsu, S. Kalaga, U. Udensi, C. Asomugha, R. Bohat, J.J. Gallegos, J.R. Seavitt, J.D. Heaney, A.L. Beaudet, M.E. Dickinson, M.J. Justice, V. Philip, V. Kumar, K.L. Svenson, R.E. Braun, S. Wells, H. Cater, M. Stewart, S. Clementson-Mobbs, R. Joynson, X. Gao, T. Suzuki, S. Wakana, D. Smedley, J.K. Seong, G. Tocchini-Valentini, M. Moore, C. Fletcher, N. Karp, R. Ramirez-Solis, J.K. White, M.H. de Angelis, W. Wurst, S.M. Thomasy, P. Flicek, H. Parkinson, S.D.M. Brown, T.F. Meehan, P.M. Nishina, S.A. Murray, M.P. Krebs, A.M. Mallon, K.C.K. Lloyd, C.J. Murphy, and A. Moshiri, Identification of genes required for eye development by high-throughput screening of mouse knockouts. Commun Biol, 2018. 1: p. 236.

28. Ma, H., C. Liu, B. Shi, Z. Zhang, R. Feng, M. Guo, L. Lu, S. Shi, X. Gao, W. Chen, and L. Sun, Mesenchymal Stem Cells Control Complement C5 Activation by Factor H in Lupus Nephritis. EBioMedicine, 2018. 32: p. 21-30.

29. Luan, X.R., X.L. Chen, Y.X. Tang, J.Y. Zhang, X. Gao, H.P. Ke, Z.Y. Lin, and X.N. Zhang, CRISPR/Cas9-Mediated Treatment Ameliorates the Phenotype of the Epidermolytic Palmoplantar Keratoderma-like Mouse. Mol Ther Nucleic Acids, 2018. 12: p. 220-228.

30. Lu, K., T.S. Shi, S.Y. Shen, W.L. Lu, J. Wu, K.J. Zhang, X.B. Zhu, Y. Shi, X.L. Liu, F. Yu, L. Li, H.J. Teng, X. Gao, H.X. Ju, W. Wang, C.J. Li, Q. Jiang, and B. Xue, Egr1 deficiency disrupts dynamic equilibrium of chondrocyte extracellular matrix through PPARgamma/RUNX2 signaling pathways. Am J Transl Res, 2018. 10(6): p. 1620-1632.

31. Lu, K., T. Shi, L. Li, K. Zhang, X. Zhu, S. Shen, F. Yu, H. Teng, X. Gao, H. Ju, W. Wang, and Q. Jiang, Zhuangguguanjie formulation protects articular cartilage from degeneration in joint instability-induced murine knee osteoarthritis. Am J Transl Res, 2018. 10(2): p. 411-421.

32. Lin, Z., F. Liu, P. Shi, A. Song, Z. Huang, D. Zou, Q. Chen, J. Li, and X. Gao, Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther, 2018. 9(1): p. 47.

33. Lai, B., J. Zou, Z. Lin, Z. Qu, A. Song, Y. Xu, and X. Gao, Haploinsufficiency of hnRNP U Changes Activity Pattern and Metabolic Rhythms. Am J Pathol, 2018. 188(1): p. 173-183.

34. Geng, L., S. Wang, X. Li, D. Wang, H. Chen, J. Chen, Y. Sun, W. Chen, G. Yao, X. Gao, W. Chen, S. Shi, X. Feng, and L. Sun, Association between Type I interferon and depletion and dysfunction of endothelial progenitor cells in C57BL/6 mice deficient in both apolipoprotein E and Fas ligand. Curr Res Transl Med, 2018. 66(3): p. 71-82.

35. Geng, L., X. Tang, K. Zhou, D. Wang, S. Wang, G. Yao, W. Chen, X. Gao, W. Chen, S. Shi, N. Shen, X. Feng, and L. Sun, MicroRNA-663 induces immune dysregulation by inhibiting TGF-beta1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Cell Mol Immunol, 2018.

36. Dai, J., S. Zhou, Q. Ge, J. Qin, D. Chen, Z. Xu, D. Shi, J. Li, H. Ju, Y. Cao, M. Zheng, C.J. Li, X. Gao, H. Teng, and Q. Jiang, Bi-directional regulation of cartilage metabolism by inhibiting BET proteins-analysis of the effect of I-BET151 on human chondrocytes and murine joints. J Orthop Surg Res, 2018. 13(1): p. 118.

37. Chen, Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z. Huang, J. Ren, Z. Lin, and X. Gao, GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol, 2018.

38. Wang, Q., S. Jiang, A. Song, S. Hou, Q. Wu, L. Qi, and X. Gao, HOXD-AS1 functions as an oncogenic ceRNA to promote NSCLC cell progression by sequestering miR-147a. Onco Targets Ther, 2017. 10: p. 4753-4763.

39. Song, A., S. Jiang, Q. Wang, J. Zou, Z. Lin, and X. Gao, JMJD3 Is Crucial for the Female AVPV RIP-Cre Neuron-Controlled Kisspeptin-Estrogen Feedback Loop and Reproductive Function. Endocrinology, 2017. 158(6): p. 1798-1811.

40. Meehan, T.F., N. Conte, D.B. West, J.O. Jacobsen, J. Mason, J. Warren, C.K. Chen, I. Tudose, M. Relac, P. Matthews, N. Karp, L. Santos, T. Fiegel, N. Ring, H. Westerberg, S. Greenaway, D. Sneddon, H. Morgan, G.F. Codner, M.E. Stewart, J. Brown, N. Horner, M. Haendel, N. Washington, C.J. Mungall, C.L. Reynolds, J. Gallegos, V. Gailus-Durner, T. Sorg, G. Pavlovic, L.R. Bower, M. Moore, I. Morse, X. Gao, G.P. Tocchini-Valentini, Y. Obata, S.Y. Cho, J.K. Seong, J. Seavitt, A.L. Beaudet, M.E. Dickinson, Y. Herault, W. Wurst, M.H. de Angelis, K.C.K. Lloyd, A.M. Flenniken, L.M.J. Nutter, S. Newbigging, C. McKerlie, M.J. Justice, S.A. Murray, K.L. Svenson, R.E. Braun, J.K. White, A. Bradley, P. Flicek, S. Wells, W.C. Skarnes, D.J. Adams, H. Parkinson, A.M. Mallon, S.D.M. Brown, and D. Smedley, Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet, 2017. 49(8): p. 1231-1238.

41. Li, X., Y. Liu, Y. Wang, J. Liu, X. Li, H. Cao, X. Gao, and S.J. Zheng, Negative Regulation of Hepatic Inflammation by the Soluble Resistance-Related Calcium-Binding Protein via Signal Transducer and Activator of Transcription 3. Front Immunol, 2017. 8: p. 709.

42. Li, F., X. Hao, Y. Chen, L. Bai, X. Gao, Z. Lian, H. Wei, R. Sun, and Z. Tian, The microbiota maintain homeostasis of liver-resident gammadeltaT-17 cells in a lipid antigen/CD1d-dependent manner. Nat Commun, 2017. 7: p. 13839.

43. Karp, N.A., J. Mason, A.L. Beaudet, Y. Benjamini, L. Bower, R.E. Braun, S.D.M. Brown, E.J. Chesler, M.E. Dickinson, A.M. Flenniken, H. Fuchs, M.H. Angelis, X. Gao, S. Guo, S. Greenaway, R. Heller, Y. Herault, M.J. Justice, N. Kurbatova, C.J. Lelliott, K.C.K. Lloyd, A.M. Mallon, J.E. Mank, H. Masuya, C. McKerlie, T.F. Meehan, R.F. Mott, S.A. Murray, H. Parkinson, R. Ramirez-Solis, L. Santos, J.R. Seavitt, D. Smedley, T. Sorg, A.O. Speak, K.P. Steel, K.L. Svenson, S. Wakana, D. West, S. Wells, H. Westerberg, S. Yaacoby, and J.K. White, Prevalence of sexual dimorphism in mammalian phenotypic traits. Nat Commun, 2017. 8: p. 15475.

44. Fu, G., Q. Xu, Y. Qiu, X. Jin, T. Xu, S. Dong, J. Wang, Y. Ke, H. Hu, X. Cao, D. Wang, H. Cantor, X. Gao, and L. Lu, Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med, 2017. 214(5): p. 1453-1469.

45. Bowl, M.R., M.M. Simon, N.J. Ingham, S. Greenaway, L. Santos, H. Cater, S. Taylor, J. Mason, N. Kurbatova, S. Pearson, L.R. Bower, D.A. Clary, H. Meziane, P. Reilly, O. Minowa, L. Kelsey, G.P. Tocchini-Valentini, X. Gao, A. Bradley, W.C. Skarnes, M. Moore, A.L. Beaudet, M.J. Justice, J. Seavitt, M.E. Dickinson, W. Wurst, M.H. de Angelis, Y. Herault, S. Wakana, L.M.J. Nutter, A.M. Flenniken, C. McKerlie, S.A. Murray, K.L. Svenson, R.E. Braun, D.B. West, K.C.K. Lloyd, D.J. Adams, J. White, N. Karp, P. Flicek, D. Smedley, T.F. Meehan, H.E. Parkinson, L.M. Teboul, S. Wells, K.P. Steel, A.M. Mallon, and S.D.M. Brown, A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nat Commun, 2017. 8(1): p. 886.

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47. Hou S, Xian L, Shi P, Li C, Lin Z*, Gao X* (2016) The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice. Sci Rep, 6:26735.

48. Jiang H, Shi H, Sun M, Wang Y, Meng Q, Guo P, Cao Y, Chen J, Gao X, Li E, Liu J* (2016) PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense. J Immunol, 197:2880-2890.

49. Jiang S, Wang Q, Huang Z, Song A, Peng Y, Hou S, Guo S, Zhu W, Yan S, Lin Z*, Gao X* (2016) Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice. Am J Pathol, 186:2117-2128.

50. Lai SS, Zhao DD, Cao P, Lu K, Luo OY, Chen WB, Liu J, Jiang EZ, Yu ZH, Lee G, Li J, Yu DC, Xu XJ, Zhu MS, Gao X*, Li CJ*, Xue B* (2016) PP2Acalpha positively regulates the termination of liver regeneration in mice through the AKT/GSK3beta/Cyclin D1 pathway. J Hepatol, 64(2):352-360.

51. Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega RB, Zhu MS, Kelly DP, Gao X, Gan Z* (2016) Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med, 8:1212-1228.

52. Lyu YS, Shi PL, Chen XL, Tang YX, Wang YF, Liu RR, Luan XR, Fang Y, Mei RH, Du ZF, Ke HP, Matro E, Li LE, Lin ZY, Zhao J, Gao X, Zhang XN* (2016) A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy. Mol Thera Nuc Acids, 5:e299.

53. Tang A, Shi P, Song A, Zou D, Zhou Y, Gu P, Huang Z, Wang Q, Lin Z*, Gao X* (2016) PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte. Cell Cycle, 15:1450-1461.

54. Wang X, Li MM, Zhao J, Li S, MacDonald MR, Rice CM, Gao X, Gao G* (2016) Sindbis Virus Can Exploit a Host Antiviral Protein To Evade Immune Surveillance. J Virol, 90:10247-10258.

55. Chen W, Huang Z, Jiang X, Li C, *Gao X (2016) Overexpression of myeloid differentiation protein 88 in mice induces mild cardiac dysfunction, but no deficit in heart morphology. Braz J Med Biol Res. 49: e4794

56. Dong D, Li L, Gu P, Jin T, Wen M, Yuan C, Gao X, Liu C, Zhang Z (2015) Profiling metabolic remodeling in PP2Acα deficiency and chronic pressure overload mouse hearts. FEBS Lett. 589:3631-9

57. Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du J, Li CJ, Gan ZJ, Gao X, Chen HQ, Zhu MS (2015) Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proc Natl Acad Sci U S A. 112:13627-32

58. Miller M, Beppu A, Rosenthal P, Pham A, Das S, Karta M, Song DJ, Vuong C, Doherty T, Croft M, Zuraw B, Zhang X, Gao X, Aceves S, Chouiali F, Hamid Q, Broide DH (2015) Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M. J Immunol. 195:3546-56

59. Li L, Zeng Z, Qi Z, Wang X, Gao X, Wei H, Sun R, Tian Z (2015) Natural Killer Cells-Produced IFN-γ Improves Bone Marrow-Derived Hepatocytes Regeneration in Murine Liver Failure Model. Sci Rep. 5:13687

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基金种类	基金项目名称
中国科学技术部	发育编程及其代谢调节
中国科学技术部	建立国家突变小鼠研究中心
中国科学技术部	通过ENU诱变大规模筛选突变小鼠
江苏省科技厅	用微阵列分析糖尿病小鼠肾脏的基因表达谱
中国科学技术部	几种小鼠疾病模型的表型分析
中国科学技术部	中国小鼠生物信息学数据库平台的建立
中国教育部	肿瘤转移中的PRL-3信号传导
中国自然科学基金	TLR信号在心脏肥大发育调节中的作用
中国教育部	基于血管分子生物学的药物发现和开发
中国科学技术部	先天性心脏病发生和筛选小鼠突变体
中国自然科学基金	杰出青年学者基金会
中国科学技术部	为疾病模型生成小鼠突变体
江苏省科技厅	中国突变小鼠资源中心创新研究
中国科学技术部	使用CRISPR / Cas9技术系统生成大鼠疾病模型
中国自然科学基金	用染色体置换研究野生小鼠基因组异质性
江苏省科技厅	开发用于药物研发的新型小鼠模型
中国科学技术部	为NRCMM建立无菌小鼠设施

Co-PI：
林兆宇 linzy@nicemice.cn
硕士生：
陈芊月 chenqy@nicemice.cn	郑尚 zhengshang@nicemice.cn	孙旻瓅 sunlm@nicemice.cn
康路路 kangll@nicemice.cn	王迪 wangdi@nicemice.cn
博士生：
邹玉洁 zouyj@nicemice.cn	李旭 lixu@nicemice.cn	裴静文 peijw@nicemice.cn
刘其耀 liuqy@nicemice.cn	刘樾 liuyue@nicemice.cn
技术员：
邹家风	邹家香
毕业学生：

孔栋	沙海波	余明艳	贺芳	曾虎
阮海斌	顾星星	鲍洁	赵静	齐心
唐晶	葛晓梅	陈维倩	高艳	徐静悦
蒋璇	周玥	熊熙文	顾鹏宇	林兆宇
任凯群	严虹	李颖倩	黄赞	侯思源
冼黎	宋安营	唐安	王庆华	邹耩欢
蒋淑君	孙敏	史培良	赖贝贝	陈秦
邹达远	王鼎玉	王雨芳

高翔实验室

神经生物学

器官发育

代谢与免疫

干细胞及肿瘤生物学

友情链接：