陈炯实验室

研究方向:

       主要以果蝇为模式动物，从事发育生物学、细胞生物学、遗传学方面的研究。主要研究方向有 1）肌动蛋白细胞骨架的一些重要调控因子在果蝇眼发育中上皮层形态发生的功能和作用，2）肌动蛋白细胞骨架的重要调控因子在正常发育的细胞迁移中以及可能在肿瘤转移中作用的分子机制，3）大规模的功能基因组筛选来发现在细胞迁移中和其他发育过程中的新(novel)基因。

1.   Wang, H., Qiu, Z., Xu, Z., Chen, S., Luo, J., Wang, X.*and Jiong Chen*. aPKC is a key polarity molecule coordinating the function of three distinct cell polarities during collective migration, Development (2018)

2.   Kang, D., Wang, D., Xu, J., Quan, C., Guo1, X., Wang, H., Luo, J., Yang, Z., Chen, S.* and Jiong Chen*. The InR/Akt/TORC1 growth-promoting signaling negatively regulates JAK/STAT activity and migratory cell fate during morphogenesis, Developmental Cell (2018)

3.   Xiao Y, Ma HX, Wan P, Qin DD, Wang XX, Zhang XX, Xiang YL, Liu WB, Chen J, Yi ZH, Li L (2017) Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation. Journal of Biological Chemistry 292: 1438-1448.

4.   Zhu KA, Liu MH, Fu Z, Zhou Z, Kong Y, Liang HW, Lin ZG, Luo J, Zheng HQ, Wan P, Zhang JF, Zen K, Chen J, Hu FL, Zhang CY, Ren J, Chen X (2017) Plant microRNAs in larval food regulate honeybee caste development. Plos Genetics 13: e1006946.

5.   Wu, J., Wang, H., Xuan, G., Chen, J.* Cofilin-mediated actin dynamics promotes actin bundle formation during Drosophila bristle development Molecular Biology of the Cell (2016)

6.   Luo, Jun, Heng Wang, Di Kang, Xuan Guo, Ping Wan, Dou Wang, and Jiong Chen*. "Dlg5 maintains apical polarity by promoting membrane localization of Crumbs during Drosophila oogenesis." Scientific reports (2016).

7.   Xu, J., Wan, P., Wang, M., Zhang, J., Gao, X.,Hu, B., Han, J.,Chen, L., Sun, K., Wu, J.,*, Wu. X.,*, Huang, X.,* and Chen, J.*AIP1-mediated actin disassembly is required for postnatal germ cell migration and spermatogonial stem cell niche establishment Cell Death & Disease(2015)

8.   Luo, J., Zuo J., Wu J., Wan., P., Kang, D., Xiang, C., and Chen, J.*in vivo RNAi screen identifies candidate signaling genes required for collective cell migration in Drosophila ovary Science China: Life Sciences(2015)

9.   Yuan, B., Wan, P., Chu, D., Nie, J., Cao, Y., Luo, W., Lu, S., Chen, J.*, Yang, Z*.  A Cardiomyocyte-Specific Wdr1 Knockout Demonstrates Essential Functional Roles for Actin Disassembly during Myocardial Growth and Maintenance in Mice. American Journal of Pathology  184(7):1967-80  (2014).

10. Wan, P., Wang, D., Luo, J., Chu, D., Wang, H., Zhang, L., and Chen, J.*  Guidance receptor promotes asymmetric distribution of Exocyst and recycling endosome during collective cell migration  Development  (2013).

11. Chu, D., Pan, H., Wan, P., Wu, J., Luo, J., Zhu, H. and Chen, J.*  AIP1 Acts with Cofilin to Control Actin Dynamics during Epithelial Morphogenesis  Development 139:3561-3571. (2012)

12. Zhang, L., Luo, J., Wan, P., Wu, J., Laski, F. and Chen, J.*  Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis. Development 138, 455-64. (2011)

13. Wang, D., Zhang, L., Zhao, G., Wahlstrom, G., Heino, T. I., Chen, J.*. and Zhang, Y. Q. *  Drosophila twinfilin is required for cell migration and synaptic endocytosis. Journal of Cell Sciences 123, 1546-56. (2010)

14. Call, Gerald, Olson, J., Chen, J. et al. Genome-wide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X-chromosome and autosomes. Genetics 177(2):689-97 (2007)

15. Chen, Jiong, Call, G., Undergraduate Research Consortium in Functional Genomics (URCFC), and Banerjee, U.  Discovery-based science education: functional genomic dissection in Drosophila by undergraduates.  PLoS Biology. 3(2): e59 (2005).

16. Couderc, J., Godt, D., Zollman, S., Chen, J., Tiong, S., Li, M., Cramton, S., Sahut-Barnola, I., and Laski, F.  The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins, and acts as a homeotic and morphogenetic regulater of imaginal development in Drosophila.  Development 129(10): 2419-33 (2002).

17. Chen, Jiong, Dorothea Godt, Kris Gunsalus, Istvan Kiss, Michael Goldberg and Frank A. Laski. Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis. Nature Cell Biology  3(2), 204-209 (2001).