陈贵泉实验室

Recent publications (*, corresponding author):

1. Xia Y, Zhang Y, Xu M, Zou X, Gao J*, Ji M*, and Chen G*, Presenilin enhancer2 is crucial for the transition of apical progenitors to neurons but not basal progenitors in the developing hippocampus. Development, 2022.

2. Teng X, Hu P, Chen Y, Zang Y, Ye X, Ou J, Chen G*, and Shi YS*, A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice. FASEB J, 2022. 36: e22212.

3. Wang H, Liu M, Ye Z, Zhou C, Bi H, Wang L, Zhang C, Fu H, Shen Y, Yang J, Hu Y*, Chen G*. Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1. Journal of Neuroscience 2021 (41): 8163-8180.

4. Hou J, Bi H, Ye Z, Huang W, Zou G, Zou X, Shi Y, Shen Y, Ma Q, Kirchhoff F, Hu Y*, Chen G*. Pen-2 negatively regulates the differentiation of oligodendrocyte precursor cells into astrocytes in the central nervous system. Journal of Neuroscience 2021 (41):4976-4990.

5. Wang Q, Gong L, Mao S, Yao C, Liu M, Wang Y, Yang J, Yu B, Chen G*, Gu X*. Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury. Experimental Neurology 2021 (343):113788.

6. Wang H，Liu M，Zou G，Wang L, Duan W，He X, Ji M，Zou X, Hu Y*, Yang J*，Chen G*. Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system. Neurobiology of Disease 2021 (148): 105212.

7. Wu J, Shao C, Ye X, Di X, Li D, Zhao H, Zhang B*, Chen G*, Liu H-K*, Qian Y* (2021) In vivo brain imaging of amyloid-b aggregates in Alzheimer's disease with a near-infrared fluorescent probe. ACS Sensors 2021 (6):863-870.

8. Bi H，Zhou C，Zhang Y，Cai X，Ji M，Yang J，Chen G*, Hu Y*. Neuron-specific deletion of presenilin enhancer2 causes progressive astrogliosis and agerelated neurodegeneration in the cortex independent of the Notch signaling. CNS Neuroscience & Therapeutics 2021 (27): 174-185.

9. Zhang T, Ding H, Wang Y, Yuan Z, Zhang Y, Chen G*, Xu Y*, Chen L*. Akt3-mTOR regulates hippocampal neurogenesis in adult mouse. Journal of Neurochemistry 2021:15441.

10. Huang C, Liu T, Wang Q, Hou W, Zhou C, Song Z, Shi YS, Gao X, Chen G*, Yin Z* and Hu Y*. Loss of PP2A disrupts the retention of radial glial progenitors in the telencephalic niche to impair the generation of late-born neurons during cortical development (Cover story). Cerebral Cortex 2020 (30):4183-4196.

11. Ma X, Wang Y, Hua J, Xu C, Yang T, Yuan J, Chen G*, Guo Z* and Wang X*. Aβ-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer’s disease (Cover story). Science China Chemistry 2020 (63):73-82.

12. Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Shi Y, Zheng Y, Lu J* and Chen G*. Conditional inactivation of Pen-2 in the developing neocortex leads to rapid switch of apical progenitors to basal progenitors. Journal of Neuroscience 2019 (39):2195-2207.